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Saturday, 6 June 2020

New killing mechanism discovered in ‘game-changing’ antibiotic



Scientists at the University of Liverpool and University of Utrecht have taken another step forward on their quest to develop a viable drug based on teixobactin – a new class of potent natural antibiotic capable of killing superbugs.

Research published today in Nature Communications provides fundamental new insights into how teixobactins kill bacteria, including the discovery of a new killing mechanism that could help inform the design of improved teixobactin-based drugs.

Teixobactin was hailed as a “game changer” when it was discovered in 2015 due to its ability kill multi-drug resistant bacterial pathogens such as MRSA without developing resistance. If made suitable for humans, it would mark the first new class of antibiotic drug for 30 years.



Dr Ishwar Singh, an expert in Antimicrobial Drug Discovery and Development and Medicinal Chemistry at Liverpool’s Centre of Excellence in Infectious Diseases Research, has led pioneering research over the past six years to develop teixobactin-based viable drugs. His research team was the first in the world to successfully create simplified synthetic forms of teixobactins which are effective in treating bacterial infections in mice.

Dr Singh explained: “We know that the therapeutic potential of simplified synthetic teixobactins is immense, and our ultimate goal is to have a number of viable drugs from our synthetic teixobactin platform which can be used as a last line of defence against superbugs to save lives.”

In collaboration with NMR expert Professor Markus Weingarth at the University of Utrecht, the team used high resolution solid state NMR, and microscopy to show, for the first time, how synthetic teixobactins bind to lipid II (an essential component of the bacterial membrane) and kill the bacteria.
Dr Singh said: “It had been assumed that teixobactins kill the bacteria by binding to bacterial cell wall bricks such as lipid II, but never shown until now. Our work also suggests that teixobactins kill the bacteria by capturing lipid II in massive clusters, a new killing mechanism, which we were excited to discover.”

Antimicrobial resistance (AMR) is a grave threat to human health and prosperity. The O’Neill report, commissioned by the UK government and published in 2016, suggests that without action AMR will cause the deaths of 10 million people a year by 2050. The development of new antibiotics is therefore a crucial area of study for scientists around the world.
Dr Singh added: “A significant amount of work remains in the development of teixobactins as a therapeutic antibiotic for human use. Our study is a real step in right direction and opens the door for improving teixobactins and moving these toward clinic.



“So far, we have demonstrated that we can make teixobactins which are effective in treating infections from resistant bacterial pathogens and understand their binding modes in a bacterial membrane. Now we need to expand our understanding on mode of action on a library of teixobactins with different bacterial membranes to develop a catalogue of molecules which have potential to become a drug for human use.”


Research reference
Shukla, R., Medeiros-Silva, J., Parmar, A. et al. Mode of action of teixobactins in cellular membranes. Nat Commun 11, 2848 (2020). https://doi.org/10.1038/s41467-020-16600-2 

9 comments:

  1. I was infected with Genital Herpes Virus 10 month ago, ever since then i have been searching for cure everywhere because i was feeling so uncomfortable with it. I have been dating for almost 5 years until i contracted Genital Herpes from my ex-boyfriend. since then I became very  sad about the whole situation, always going online checking if i could get a cure to Genital Herpes, then i came across so many testimonies. Due to my seriousness and eagerness to be completely cured, i became a victim of fraud after contacting several so-called herbal doctors i was referred to. I lost a lot of money but i didn't stop searching for a cure. Then one faithful day, i came across a testimony of a lady saying that she got her Genital herpes cured by a Great Herbal Doctor she called Dr iniboku by contacting him through his email address. And she advised anyone with Genital Herpes or Simplex Herpes to contact the herbal doctor for Herbal Cure. I contemplated for about 4 hours whether or not to contact him. then something inside of me told me 'Nothing good comes easy'. I then contacted him through his email and told him my problem. He told me all the things I needed to do and also gave me instructions to follow, which i did properly. Just within weeks of drinking and applying the herbal medication he sent to me through DHL delivery service, i started seeing changes, i went to my medical doctor for check-up, i was so happy when the doctor told me i was no more having Genital Herpes Virus, it was all tears of Joy from that moment, People think herpes is really a minor skin irritation herpes has a long term effects on health and if i could ever meet a Genuinely Great Herbal Doctor. I'm so grateful to him. i am completely free from Genital Herpes Virus, i introduced a family friend who have Simplex Herpes virus to him, He called me and told me he was also cure completely. I promised to share my own testimony like that of the lady on the internet. Friends, If you are also struggling with Herpes disease you can as well Contact him via Email: drinibokuspelltemple@gmail.com him on via whatsApp at +2347059186346

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    1. Traditional Herbal doctor Sayo Cure HSV-2 Disease
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      Traditional Herbal doctor Sayo Cure HSV-2 Disease
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    2. HOW I GOT CURED FROM HERPES VIRUS I was diagnosed of HERPES virus and i have tried all I can to get cured but all to no avail,,until I saw a post in a health forum about a herbalist man who prepare herbal medications to cure all kind of diseases including HERPES vivvrus,at first I doubted if it was real but decided to give it a try,when I contacted this herbalist via his email and he prepared a HERPES herbal cure and sent it to me via Drosalumese delivery company service, when I received this herbal medicine, he gave me step by direction on how to apply it,after applying the way I was instructed,I was totally cured of this deadly disease called HERPES, all thanks to Dr osalumese ..Email this great herbal doctor via his email drosalumese@gmail .com) or whatsapp him Via:+2349034455391 HE CAN ALSO CURE SICKNESS LIKE{1}HIV/AIDS{2}DIABETES{3}EPILEPSY{4} BLOOD CANCER{5} HPV{6} ALS{7} HEPATITIS{8}LOVE SPELL{9} SICKLE AND ANAEMIABeware Of Fake Doctors And Anybody Using This Testimony Again Is a Scam Only Drosalumese Can Help You I Love You Father Drosalumese

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