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Monday, 17 August 2020

Research: Cannabidiol (CBD) improves blood flow to brain’s hippocampus


Researchers say the findings could be an important discovery for conditions which affect memory, such as Alzheimer’s disease and post-traumatic stress disorder (PTSD), and could help better target therapies.

In the study, published in the Journal of Psychopharmacology, researchers set out to investigate how CBD influences cerebral blood flow in different regions on the brain involved in memory processing.



Lead author, Dr Michael Bloomfield (UCL Psychiatry) said: “Cannabidiol is one of the main constituents of cannabis and is gaining interest for its therapeutic potential.

“There is evidence that CBD may help reduce symptoms of psychosis and anxiety. There is some evidence to suggest that CBD may improve memory function.

“Additionally, CBD changes how the brain processes emotional memories, which could help to explain its reputed therapeutic effects in PTSD and other psychiatric disorders. However, the precise mechanisms underlying the effects of CBD on memory are unclear.”

For the randomised controlled study, 15 healthy young adult participants, with little or no history of cannabis use were selected.

On different occasions, separated by at least a week, each participant was given a 600mg of oral CBD or a placebo. The doses came in identical capsules, so participants didn’t know which one they were taking on which occasion.

Researchers measured blood flow to the hippocampus using ‘arterial spin labelling’ – a magnetic resonance imaging (MRI) brain scanning technique which measures changes in the blood oxygen levels.

Findings

CBD significantly increased blood flow in the hippocampus, however CBD did not cause significant differences in blood flow in other regions of the medial temporal lobe (MTL), of which the hippocampus is a significant component.

In the prefrontal cortex, the area of the brain used for planning and decision making, CBD caused a significant increase in blood flow in the orbitofrontal cortex.

Dr Bloomfield added: “To our knowledge, this is the first study to find that CBD increases blood flow to key regions involved in memory processing, particularly the hippocampus.

“This supports the view that CBD has region-specific blood flow effects in the human brain, which has previously been disputed.

“If replicated, these results could lead to further research across a range of conditions characterised by changes in how the brain processes memories, including Alzheimer’s disease, where there are defects in the control of blood control flow, along with schizophrenia and post-traumatic stress disorder.”

Study limitations

This study used a single dose of CBD in healthy volunteers, which may not translate to the effects of repeated CBD dosing.



Reference: 

Michael Bloomfield et al. The effects of acute cannabidiol on cerebral blood flow and its relationship to memory: An arterial spin labelling magnetic resonance imaging study. Journal of Psychopharmacology. DOI: doi/10.1177/0269881120936419

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