A breakthrough in quantum imaging could lead to the development of advanced
forms of microscopy for use in medical research and diagnostics.
A team of physicists from the University of Glasgow and Heriot-Watt
University have found a new way to create detailed microscopic images under
conditions which would cause conventional optical microscopes to fail.
In a new paper published today in the journal Nature Photonics, the team
describe how they have generated images by finding a new way to harness a
quantum phenomenon known as Hong-Ou-Mandel (HOM) interference.
Named after the three researchers who first demonstrated it in 1987, HOM
interference occurs when quantum-entangled photons are passed through a beam
splitter—a glass prism which can turn a single beam of light into two
separate beams as it passes through. Inside the prism, the photons can
either be reflected internally or transmitted outwards.
When the photons are identical, they will always exit the splitter in the
same direction, a process known as 'bunching'. When the entangled photons
are measured using photodetectors at the end of the path of the split beam
of light, a characteristic 'dip' in the output probability graph of the
light shows that the bunched photons are reaching only one detector and not
the other.
That dip is the Hong-Ou-Mandel effect, which demonstrates the perfect
entanglement of two photons. It has been put to use in applications like
logic gates in quantum computers, which require perfect entanglement in
order to work.
It has also been used in quantum sensing by putting a transparent surface
between one output of the beam splitter and the photodetector, introducing a
very slight delay into the time it takes for photons to be detected.
Sophisticated analysis of the delay can help reconstruct details like the
thickness of surfaces.
Now, the Glasgow-led team has applied it to microscopy, using single-photon
sensitive cameras to measure the bunched and anti-bunched photons and
resolve microscopic images of surfaces.
In the Nature Photonics paper, they show how they have used their setup to
create high-resolution images of some clear acrylic sprayed onto a
microscope slide with an average depth of 13 microns and a set of letters
spelling 'UofG' etched onto a piece of glass at around 8 microns deep.
Their results demonstrate that it is possible to create detailed, low-noise
images of surfaces with a resolution of between one and 10 microns,
producing results close to that of a conventional microscope.
Professor Daniele Faccio, of the University of Glasgow's School of Physics
and Astronomy, is the paper's lead author. Professor Faccio said:
"Conventional microscopy using visible light has taught us a vast amount
about the natural world and helped us make an incredible array of
technological advances.
"However, it does have some limitations which can be overcome by using
quantum light to probe the microscopic realm. In bioimaging, where cells can
be almost entirely transparent, being able to examine their fine details
without using conventional light could be a major advantage—we chose to
image transparent surfaces in this research precisely to demonstrate that
potential.
"Similarly, samples in conventional microscopes need to be kept perfectly
still—introducing even a small vibration could introduce a level of blur
which would ruin an image. However, HOM interference requires only measuring
photon correlations and there is much less need for stability.
"Now that we've established that it's possible to build this kind of quantum
microscopy by harnessing the Hong-Ou-Mandel effect, we're keen to improve
the technique to make it possible to resolve nanoscale images. It will
require some clever engineering to achieve, but the prospect of being able
to clearly see extremely small features like cell membranes or even strands
of DNA is an exciting one. We're looking forward to continuing to refine our
design."
Reference:
Bienvenu Ndagano et al, Quantum microscopy based on Hong–Ou–Mandel
interference, Nature Photonics (2022).
DOI: 10.1038/s41566-022-00980-6
Tags:
Physics